Monocyte Chemoattractant Protein-1 Modulates Invasion and Apoptosis of PC-3M Cells
نویسندگان
چکیده
Prostate cancer is a form of malignancy that most likely develops in older males. It is the second leading cause of cancer death in American men. Because prostate cancer may metastasize to other parts of the body, particularly the bones, prostate cancer has deleterious impact on the survival and quality of living for patients. In fact about 80% patients who die of prostate cancer develop bone metastasis (Loberg et al., 2005; Taichman et al., 2007). Therefore, investigation of molecular mechanisms underlying the metastasis of prostate cancer to bone will be important for the prevention and therapy of prostate cancer metastasis. Monocyte chemoattractant protein-1 (MCP-1)/CCL2, is an inducible CC-chemokine that binds its G protein coupled receptor (GPCR), CCR2 and plays a vital role in the recruitment and activation of monocytes during inflammation (Rossi and Zlotnik, 2000). More recent studies have demonstrated that MCP-1 plays crucial role in the growth, invasion, and metastasis of prostate cancer (Loberg et al., 2006; 2007b; Lu et al., 2006). Therefore, in this study we employed a highly metastatic prostate cancer cell line PC-3M as an in vitro model to characterize the effect of MCP-1 on the cellular
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تاریخ انتشار 2011